The Colorado basin has an area of approximately 120.000 km2, most of them corresponding to the continental shelf and slope, where it reaches water depths greater than 3900 m. Maximum sedimentary thicknesses are greater than 12.000 m in the eastern depocenter. The stratigraphic column begins with a pre-refit section of mainly Paleozoic rocks, followed by syn-rift fluvial and lacustrine deposits of Jurassic age and, ultimately, by cretaceous fluvio-deltaic to marine sag deposits and later by Cretaceous and Cenozoic deep marine passive margin deposits. There are several levels that could act as possible source rocks, reservoirs and seals and even certain clues of the existence of a working petroleum system, confirmed by the well Cruz del Sur in the 1980s. A highlight of the Colorado basin is the so-called External High. This feature is a huge structure located at the external part of the Colorado basin, separating it from the North Argentina basin. This basement high shows normal faulting in its flanks, associated with the reactivation of the faults involved in the formation of the different cretaceous basin depocenters. Moreover, in its formation it is highly probable the contribution of differential compaction. Based on the analysis of the elements extracted from seismic interpretation, like stacking patterns, geometries, geomorphology, thicknesses and the utilization of concepts of base level and geological time lines (Wheeler, 1958, 1964) it is possible to identify areas with high hydrocarbon generation potential, reservoir zones and seals, and to evaluate its lateral continuity and spatial distribution. This regional characterization of the petroleum system elements could strengthen prospect exploration and trigger new questions for the study area. To complement the conventional workflows, semi-automatic interpretation flows were used on the totality of the seismic data that allowed associating geological ages relative to all horizons and building a lithostratigraphic framework to deepen the understanding of stratigraphic evolution. In this way it would be possible to synthesize the knowledge in a practical way for its application in exploratory prospecting.