Despite many previous paleoceanographic, paleontological and geologic studies in Panama, Colombia, and western Venezuela and their offshore areas, the debate continues on the the age of the initial collision of Panama with interpretations ranging widely from Oligocene (25 Ma) to Late Pliocene (2.8 Ma) along with how this event was manifested in the regional subaerial and marine geology. In order to address these questions, we present: 1) a regional depth-to-top crystalline basement map of both on- and offshore areas; 2) integration of thermochronologic data from the Colombian Geochronological Database (CGD); 3) updating of on- and offshore paleogeographic maps using recent data acquired in the past decade; 4) defining areas of angular unconformities and their ages; 5) generation of burial plots, sedimentary thickness and isopach maps from basins in Colombia and western Venezuela; 5) compilation of GPS data and late Quaternary fault zones; and 7) mapping of regional distribution of seeps, producing wells and giant oil and gas fields. Results from these compilations include: 1) collision of the Panama arc marked a regional event of uplift of basement blocks with thermochronology showing a main phase of cooling and exhumation during the late Miocene-Pliocene (12-4 Ma): 2) basement uplift and erosion in a tropical climate produced clastic wedges in on- and offshore clastic basins; 3) the development of the north-flowing and strike-parallel Cauca, Magdalena and Maracaibo river systems formed a continuous source of clastic sediments into the Caribbean sedimentary basins especially with the development of the Magdalena submarine fan; 4) the Panama collision creates a wave of Late Miocene to Recent (13-0 Ma) hydrocarbon maturation and migration that encompasses the Maracaibo, Llanos, Middle Magdalena Valley and Catatumbo basins; and 5) the Antioquia plateau areas of western Colombia, an area of thinly preserved sedimentary rocks is related to the presence of the inferred Panama indentor.